Gurevich K. G.
Regularities and
Possible Mechanisms of Action of Supersmall Dozes of Biologically Active
Substances
Abstract
The
basic laws of action of supersmall dozes of biologically active substances
(BAS) in supersmall dozes are considered. The variability, observable in many
experiments, of the data can be explained at the expense of linkage of
individual molecules BAS from their effectors, thus, proceeding from
theoretical accounts, factor of a variation is equal to (N is number
of ligand-receptor complexes), that correspond to experimental data. The
developing biological answer at linkage of individual molecules, is explained
by presence of highly effective systems of receptor signal transduction and
amplification, that corresponds with the "classical" theory of the "free
receptors" by Steferson. It is possible to explain absence of the
biological answer in the field of 10-8-10-12 M by
existence of two systems with negative feedbacks (substrate inhibition,
inhibitionby surplus of a product etc.). The laws of development of the biological
answer in time are described at action of supersmall dozes: the presence of
bimodal effects is determined by the entered doze BAS.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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