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Cherkashin E. A., Fedorchuk V. V., Sidorenko S. V., Tishkov V. I.
Study of metallo-beta-lactamase occurrence in Russian Federation
Abstract
Pseudomonas aeruginosa is one of the most significant
pyoinflammatory pathogens which can cause severe suppurative complications and
even lead to lethal outcome. The wide use of carbopenemes, that are "the last
defence line" after penicillin and cephalosporin-based beta-lactame
antibiotics, brought to the appearance of Pseudomonas aeruginosa stains with high resistance level to these
antibiotics. The cause for carbopenem resistance formation is acquiring of
metallo-beta lactamase gene by pathogene stain, which is capable for digestion
of even synthetic beta-lactame antibiotics of last generation. 49 stains
of Pseudomonas aeruginosa, Klebsiella
pneumoniae and Stenotrophomonas maltophi genuses with high phenotype
resistance (MIC>8) to meropenem or imepenem from hospitals and clinics of
Moscow, St. Peterburg, Yaroslavl’, Irkutsk, Saratov, Omsk, Kazan’,
Magnitogorsk, Ekaterinburg were analysed. It was shown that 33 of 49 strains
contain metallo-beta lactamases type VIM1 and VIM2. Two strains also had
metallo-beta lactamases type IMP1 as well as VIM1.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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