Moscow University Chemistry Bulletin Vol. 48, No. 5, P. 302 (2007)

M. K. Karapetyan, U. V. Skornyakov, M. V. Proskurnina, N. S. Zefirov

Synthesis of homoinositols – a new class of mio-inozitolmonophosphataze inhibitors

Abstract

The new class of structural analogues of inositol - homoinositols, being potential inhibitors mio-inozitolmonophosphataze is offered. Key compound is adduct of Diels-Alder reaction of tetrachlorocyclopropene with furane – 2,3,4,4-tetrachloro-8-oxabicyclo [3.2.1] octadien-2,6. Next modification leads to diastereomeres of homoinositols and its derivatives.

Moscow University Chemistry Bulletin.
2007, Vol. 48, No. 5, P. 302

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