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K. V. Kudryavtsev, M. Yu. Tsentalovich

Synthesis of 5-phenyl proline derivatives with antibacterial activity

Abstract

Methyl esters of 5-aryl prolines with 4-ethenesulfonyl or 4-cyano functionality at pyrrolidine scaffold have been synthesized. 4-Ethenesulfonyl derivatives have all substituents cis to each other according X-ray analysis. All synthesized compounds in vitro inhibit S. aureus sortase SrtA.
Moscow University Chemistry Bulletin.
2007, Vol. 48, No. 5, P. 308 		   
Copyright (C) Chemistry Dept., Moscow State University, 2002
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