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A. V. Ivanov, V. G. Desyatkin
Chromatofocusing of the drugs, containing paracetamol, on
the reversed-phase sorbents
Abstract
The chromatofocusing technique was applied for linear and
quasi-linear pH-gradient formation within the reversed-phase columns, packed with
Diasorb D-130-C18и Diasorb-100-CN-mono for the first time. The optimal mobile phases
are: the start buffer – 25 mM KH2PO4 + 25% CH3CN,
pH 3,0, the eluent – 3,15 mM KH2PO4 + 25% CH3CN,
pH 6,8-7,0. The chosen chromatographic conditions were used for separation of
drugs “Maxicold” and “Efferalgan-C” by chromatofocusing technique on the
sorbent Diasorb-100-CN-mono.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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