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E. P. Svidritskiy, M. Sh. Jiang, V. I. Il’in, D. I. Dynkov, A. V. Pirogov, O. A. Shpigun
Determination of
alendronate and inorganic anions by capillary electrophoresis
Abstract
The method of the simultaneous and selective
determination of alendronate, chloride, phosphite, phosphate and
methylsulfonate was developed. These ions are the major contaminators in the
synthetic alendronic acid. Therefore, it is important to control the amounts of
these impurities because alendronic acid is a component of different pills and
drugs. The method proposed in this paper allows the separation of all ions for
4 minutes. It is possible to determine low concentrations of ions at high
concentrations of other listed ions due to excellent performance of the
separation (200 – 500 thousands of theoretical plates). Limits of the detection
are 0.4 – 2.3 ppm. The method was successfully used for the analysis of
regenerated methanesulfonic acid.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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