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E. V. Kunenkov, A. S. Kononihin, I. V. Perminova, A. V. Garmash, I. A. Popov, E. N. Nikolaev
Optimization of ionization
conditions for analysis of humic substances from natural waters using
Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass
Spectrometry (ESI FTICR MS)
Abstract
An approach to optimizing conditions of acquiring
Electrospray Ionization Fourier Transform Ion Cyclotron Resonance mass spectra
(ESI FTICR MS) was suggested. This method was employed to study the influence
of cone voltage and the composition of the solution on peak intensity in ESI
FTICR mass spectra of natural water humic substances. A presence of water in
methanol solution was shown to reduce signal intensity significantly. The
highest integral intensity of peaks selected was reached on 110 mg/l sample
solution in acetonitrile and cone voltage 3.0 kV. The number of peaks to which
molecular formulas were assigned, including doubly-charged peaks, was increased
using these conditions.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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