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E. V. Blynskaya, K. V. Alekseev, T. P. Kalmikova, S. E. Kondakov

Comparative estimation of features of pharmacokinetics of the modified medicinal form trimetazidine

Abstract

Preductal MB" ("Servier", France) and tablets of trimetazidine the modified liberation is spent comparative фapмaкoкинeтичecкoe preparation studying. Their estimation pharmacokinetics indicators, values of bioavailability is carried out. In experiences in vivo it is shown that processes of an absorption, distribution, a metabolism and deducing of trimetazidine at application of tablets of trimetazidine the modified liberation and "Preductal MB" are identical also medicinal forms are bioequivalent.
Key words: trimetazidine, pharmacokinetics, bioequivalence.
Moscow University Chemistry Bulletin.
2012, Vol. 53, No. 5, P. 344
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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