N. M. Zadymova, N. I. Ivanova Simultaneous solubilization of lipophilic drug, amlodipine, and glyceryl monolaurate in aqueous micellar solutions of Tween 80 Abstract Solubilization and co-solubilization of lipophilic amlodipine (Am – antihypertensive drug) and glyceryl monolaurate (GML – enhancer of the skin permeability) in micelles of Tween 80 (Tw) in water medium were studied using UV-spectroscopy and refractometry. Such properties of the mixed micelles (Tw + GML, Tw + Am, Tw + GML + Am) as aggregation numbers of components, locus of solubilizates, diffusion coefficients, sizes, and hydration were investigated. The ternary micelle (Tw + GML + Am) includes in 4,2-times more molecules of drug than the two-component one. It was shown that the diffusion of mixed micelles (Tw + Am, Tw + GML + Am) defines the mass transfer of Am in aqueous solutions.Key words: micelles of surfactant, solubilization, co-solubilization of drug and enhancer of the skin permeability, amlodipine, glyceryl monolaurate, Tween 80.
Copyright (C) Chemistry Dept., Moscow State University, 2002 |
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