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A. V. Eremenko, T. A. Prokopkina, V. E. Kasatkin, T. A. Osipova, I. N. Kurochkin
Screen-printed thiol-sesnsitive sensor elements
for determining the activity of butyrylcholinesterase and analysis of its
inhibitors
Abstract
A method for analyzing
thiocholine, enzyme activity of butyrylcholinesterase (BChE) and their
inhibitors using thiol-sensitive planar sensors has been proposed. Sensor
sensitivity to thiocholine is provided by mediator layer of manganese dioxide
formed on the working carbon electrode. The detection limit for BChE and its
inhibitor diazinon was 1·10-10Mи 1·10-9M, respectively. The developed approach
simplifies the analysis of inhibitors and can be used to water quality control
and environmental monitoring.
Key words: manganese
dioxide, planar sensors, butyrylcholinesterase, inhibitor.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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