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I. M. Deygen, A. M. Egorov, E. V. Kudryashova
Structure and stability of fluoroquinolons –
2-hydroxypropyl-cyclodextrin, perspective anti-tuberculosis formulations
Abstract
The host–guest complex formation of fluoroquinolons (FQ), levofloxacin,
ofloxacin and moxifloxacin with HP-β-CD was studied by spectroscopy methods. Stoichiometry and
dissociation constant of the inclusion complexes were determined. The complex
formation of FQ with HP-βCD was confirmed by
solubility studies, UV, FT-IR spectra and equilibrium dialysis. By complex
formation with HP-β-CD, the prolonged
release of levofloxacin was observed in dialysis experiments. The solubility of
fluoroquinolons was enhanced by two-five -fold after inclusion complex
formation. The research may provide basis for the development of new drug
formulations of FQ based on HP-β-CD
as a nanocarrier system.
Key words:
fluoroquinolons, 2-hydroxypropyl-β-cyclodextrin, guest-host complex, FTIR.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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