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P. S. Averin, A. V. Lopes de Gerenyu, N. G. Balabushevich

Polyelectrolyte micro- and nanoparticles with doxorubicin

Abstract

Doxorubicin-containing micro- and nanoparticles, obtained by layer-by-layer adsorption of dextran sulphate and chitosan on insoluble antibiotic-polyanion complex and further sonication, were studied. The effect of biopolymer’s molecular mass, number of polyelectrolyte layers and reaction medium pH on the content and physico-chemical properties of particles and the efficiency of doxorubicin incorporation was studied. The release of doxorubicin and mucoadhesive properties of polyelectrolyte particles were analysed in order to determine the possibility of their potential applications.
Key words: doxorubicin, мicroencapsulation, layer-by-layer biopolyelectrolyte adsorption, chitosan, dextran sulfate.
Moscow University Chemistry Bulletin.
2016, Vol. 57, No. 2, P. 120
   

Copyright (C) Chemistry Dept., Moscow State University, 2002
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