Избранные главы химии
(курсы по выбору на английском языке)
Development of new drugs: legal and economic
aspects
Лектор(ы):
н.с. А. Альтьери, доц. А.В. Куркин
The Pharma industry that attracts
so much attention it is very surprising how little is known about the inner
work. This world is a complex, nonlinear, and based on several different
value systems. The scope of this tutorial is to bring an insight in the
Pharma World and how approaches the Drug Discovery process. After a bring
introduction we are going to tackle different pragmatic aspect of the drug
discovery pipeline, ranging from science, timeline and economic. A brief
outline of the lectures are reported below (the tutorial program may be
subjected to variations/amendments before the tutorial starts)
Lecture 1: Intro to the Drug
Discovery Business World – R&D productivity & Drug Discovery Pipeline
Lecture 2: Target Selection &
Validation
Lecture 3: Hit Generation & Compound
Libraries
Lecture 4: Fragment Based Drug
Discovery Approach
Lecture 5: H2L & Optimization
– part 1 (IP, activity + selectivity)
Lecture 6: H2L & Optimization
– part 2 (ADME + tox…)
Lecture 7: Hepatotoxicity &
Drug Metabolism
Lecture 8: Antiviral &
Anticancer Drug Discovery
Lecture 9: CNS Drug Discovery
Lecture 10: in vitro studies
Lecture 11: in vivo studies &
GMP
Lecture 12: Clinical
Development
Lecture 13: Business Opportunities
in the DD world – The CRO adventure