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Belov A., Belova L., Filatov V., Belova Ye., Donskikh G., Gorbunova M.
Effects of blood plasma inhibitors on the
activity of proteases immobilized on dialdehyde cellulose
Abstract
From the Institute of Textile Materials, there is available a number of biologically active substances, immobilized
on textile carriers, including trypsin known under the brand name
Dalcex-trypsin. In addition, some preparations with an immobilized proteolytic
complex isolated from the crustacean hepatopancreas (CHP) are being developed.
The above preparations have found their application as wound coverings in
treatment of pyo-necrotic wounds of different etiologies and as cosmetological
agents as well.. It should be taken into consideration that a portion of the
covalently bound enzyme can be dissolved, as a result of the carriers
hydrolysis in form of macromolecular species. Interaction of CHP, cellulose,
dialdehyde cellulose and DAC-immobilized CHP with some endogenic trypsin
inhibitors from the blood plasma has been studied. Shown are data relating to
changes in levels of plasma inhibitors (100% is the inhibitor
content prior to any interaction).
Copyright (C) Chemistry Dept., Moscow State University, 2002
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