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Khalili A. S., Domogatsky S. P., Ruuge E. K.
A mathematical approach to enzyme treatment of
burn wounds: proteolytic activity is restricted by specific inhibitor
counterflow.
Abstract
A mathematical model of proteolytic enzyme
applied to the surface of burn wound penetration into the depth of necrotic
tissue has been considered. The model approximation describes three factors by
a series of mathematical equations:
inward-directed enzyme diffusion, counter-flow filtration of
interstitial fluid (exudates), and irreversible inactivation of the enzyme by
specific inhibitors present in exudates. Character time hierarchy is defined
for these processes.
Dependence of the main characteristics of the
enzyme therapy effect on the applied enzyme concentration has been determined.
It has been shown, that the depth of enzyme propagation into necrotic tissue is
restricted by counterflow of specific inhibitor; therefore internal stratum of
necrotic tissue layer containing unbound inhibitor protects underlying intact
tissues and granulations from proteolytic action of applied enzyme.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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