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Yu. N. Morozov, S. P. Mikhalev, V. P. Shabatin, P. N. Kolotilov, G. B. Sergeev
Cryomodification
of drugs: micronization and crystalline structures of
1-(aminomethyl)-cyclohexaneacetic acid
Abstract
Cryochemical modification
is a method of micronization and changing of crystalline structure of organic
substances, that in application to drug substations may lead to the improvement
of thiere biopharmacological properties. The method was successfully developed
for chemically labile compound named gabapentine
[1-(aminomethyl)-cyclohexaneacetic acid]. According to the data obtained by
X-ray diffraction, FTIR-spectroscopy, and differentiall scanning calorimetry
(DSC), the formation of two kinetically stable polymorphic modification of
gabapentine (forms with melting points 157 °C and 163°C), which are differ from initial
commercial one (with a melting point 153°C), was observed. These two forms are
known but advantage of present work is in developing the new method of their
production excluding the use of any solvents, that is very important for
environmental safety.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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