|
I. G. Smirnova, G. N. Gildeeva, V. V. Chistyakov
Analysis of crystalline structure and chirality of drug
substances
Abstract
The
change in substance’s crystalline state or chirality influence on physical and
chemival, pharmacotechnological features as well as bioavailability of
pharmaceuticals. It was identified that such methods as X-Ray Powder
Diffraction, infrared Fourier transform spectroscopy, differential scanning
calorimetry, optical microscopy, circular dichroism can be successfully used
for quality control of medical preparation.
Key
words: drags,
polymorphism of drag substances, polymorphic modification, assay,
UV-spectroscopy, optical isomerism, circular dichroism.
Copyright (C) Chemistry Dept., Moscow State University, 2002
|
|
