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M. I. Emelyanov, V. V. Smirnov, A. A. Litvin, G. B. Kolyvanov, E. V. Blynskaya, S. E. Kondakov
Quantitative determination of cortisol and
its metabolite in rat urine by HPLC-MS method
Abstract
The technique of quantitative determination
of cortisol and its metabolite (6-β-hydroxycortisole)
in rat urine was developed. The analysis was provided with high-performance
liquid chromatography with mass-selective detector. The limits of
quantification of cortisol and its metabolite were 1,0 and 2,5 ng/ml,
respectively.
Key words: cortisol, 6-β-hydroxycortisole, quantitative determination, HPLC-MS, drug
interaction.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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