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M. V. Lebedeva, A. F. Prokhorova, E. N. Shapovalova, O. A. Shpigun
Electrophoretic enantioseparation of
profens in water-methanol solutions using eremomycin as a chiral selector
Abstract
The possibility of electrophoretic
enantioseparation of profens in water-methanol solution of eremomycin was
demonstrated. Effect of methanol content, phosphate buffer pH, and chiral
selector concentration on enantioresolution was studied. Water-methanol run
buffer was shown to provide better reproducibility of migration times, baseline
stability compared to aqueous buffers. Analysis time in non-aqueous conditions
is less than 15 min.
Key words: capillary electrophoresis,
enantioseparation, macrocyclic antibiotics, eremomycin, profens.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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