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V. P. ZherdevA. A. Litvin, G. B. Kolyvanov, E. V. Blynskaya, M. K. Sedova, K. V. Alekseev, S. E. Kondakov
Pharmacokinetic
studies of original and generic levofloxacin tablets
Abstract
A comparativepharmacokinetic studyof
genericlevofloxacintablets(500 mg)produced inFSBI “Institute of Pharmacology them.V.V.Zakusov“RAMS,
andthe original drugcontaininglevofloxacin(500mg)tabletsTavanic®,SanofiWinthropIndustry, France. The comparativeevaluationof pharmacokinetic parameters, determine the
relativebioavailabilityof a
generic, which was108,6 ± 25,6%.
Key words: Levofloxacin, pharmacokinetics,
high performance liquid chromatography, relative bioavailability.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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