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L. Y Filatova, D. M Donovan, S. C Becker, A. D. Priyma, A. V. Kabanov, N. L. Klyachko
Investigation of structure and function of
antistaphylococcal endolysins by kinetic methods
Abstract
Peculiarities of structure and function of
phages phi11 и phi80α
antistaphylococcal endolysins were investigated by kinetic measurements. In
spite of high extent of homology in primary structure, both enzymes possess
some differences in optimal conditions of functioning. As it was shown, phage
phi11 endolysin was activated by metal cations (Ca2+, Mg2+).
Sulfhydryl groups can play an important role in catalytic processes for both
phage phi11 и phi80α
endolysins.
Key words: Staphylococcus aureus,
phage endolysins, cation of metal, structure and functions.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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