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I. S. Panina, L. Y. Filatova, A. V. Kabanov, N. L. Klyachko
Investigation of physicochemical properties
of both glutathione eroxidase I and its complexes with polyelectrolytes as
promising agents for the treatment of central nervous system diseases
Abstract
A study of kinetics of thermal inactivation
of glutathione peroxidase I was carried out. Glutathione peroxidase is an
enzyme that plays a key role in the antioxidant protection system of the body.
It was shown that oligomeric glutathione peroxidase I is inactivated by
monomolecular mechanism (37ºC, pH 7.0, the enzyme concentrations of 0.3
and 1 mg/ml). An effective way to stabilize the enzyme by polyelectrolytes of
different nature was proposed.
Key words: active forms of oxygen,
glutathione peroxidase I, polyelectrolyte, kinetic of inactivation,
stabilization.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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