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A. V Soloviev, A. K. Tomilov, Yu. N. Morozov, A. V. Shabatin, I. V. Astashova, T. I. Shabatina
Cryoforming of individual nanoforms
of chloramphenicol and its hybrid nanocomposites with silver nanoparticles
Abstract
Abstract. Individual nanoparticles of the antibacterial drug chloramphenicol were
obtained from the gas phase using the cryochemical condensation
method. Carbon dioxide (CO2)was used as the carrier gas. According
to the IR spectroscopic study, the chemical structure of chloramphenicol has not
changed during modification, however, the formation of a new polymorphic modification
is possible. Hybrid chloramphenicol nanocomposites with silvernanoparticles were
obtained by a similar method without the use of a carrier gas. According to IR
spectroscopy data, the chemical structure and crystalline form of chloramphenicol
have not changed as the result of the modification, however, there
are shifts in the vibrational bands of the molecular groups of chloramphenicol
due to donor-acceptor interactions with the surface of the dioxidine
nanoparticles. According to microscopic examination data, the size of chloramphenicol
nanocomposites with silver is 112±42 nm.
Key words: cryochemical synthesis,hybrid medicinal nanoforms, antibacterial drug chloramphenicol, silvernanoparticles,molecularclusters,carbondioxide(CO2)
Copyright (C) Chemistry Dept., Moscow State University, 2002
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